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Cleavage of Notch1 by granzyme B disables its transcriptional activity
Granzyme-mediated cell death is the main pathway for cytotoxic lymphocytes to kill virus-infected and tumour cells. A major player in this process is GrB (granzyme B), which triggers apoptosis in both caspase-dependent and caspase-independent pathways. A caspase-independent substrate of GrB is the h...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4050498/ https://ncbi.nlm.nih.gov/pubmed/21548883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110226 |
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