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Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage
Notch signaling is controlled by ligand binding, which unfolds a negative control region to induce proteolytic cleavage of the receptor. First, a membrane-proximal cleavage is executed by a metalloprotease, removing the extracellular domain. This allows γ-secretase to execute a second cleavage withi...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781502/ https://ncbi.nlm.nih.gov/pubmed/19726682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006775 |
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