IL-17A enhances IL-13 activity by enhancing IL-13-induced STAT6 activation

BACKGROUND: Increased IL-17A production has been associated with more severe asthma, however the mechanisms whereby IL-17A may contribute to IL-13-driven pathology in asthma remain unclear. OBJECTIVE: We sought to gain mechanistic insight into how IL-17A can influence IL-13-driven responses. METHODS...

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Udgivet i:J Allergy Clin Immunol
Main Authors: Hall, Sara L., Baker, Theresa, Lajoie, Stephane, Richgels, Phoebe K., Yang, Yanfen, McAlees, Jaclyn W., van Lier, Adelaide, Wills-Karp, Marsha, Sivaprasad, Umasundari, Acciani, Thomas H., LeCras, Timothy D., Myers, Jocelyn Biagini, Kovacic, Melinda Butsch, Lewkowich, Ian P.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149451/
https://ncbi.nlm.nih.gov/pubmed/27417023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.04.037
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