IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae

The cytokine IL17, and signaling via its heterodimeric IL-17RA/IL-17RC receptor, is critical for host defense against extracellular bacterial and fungal pathogens. Polarized lung epithelial cells express IL-17RA and IL-17RC basolaterally. However, their contribution to IL-17-dependent pulmonary defe...

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Pubblicato in:Cell Host Microbe
Autori principali: Chen, Kong, Eddens, Taylor, Trevejo-Nunez, Giraldina, Way, Emily E., Elsegeiny, Waleed, Ricks, David M., Garg, Abhishek V., Erb, Carla J., Bo, Meihua, Wang, Ting, Chen, Wei, Lee, Janet S., Gaffen, Sarah L., Kolls, Jay K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149406/
https://ncbi.nlm.nih.gov/pubmed/27923703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.10.003
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