Human Geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis
Geminin is an unstable inhibitor of DNA replication that negatively regulates the licensing factor CDT1 and inhibits pre-replicative complex (pre-RC) formation in Xenopus egg extracts. Here we describe a novel function of Geminin. We demonstrate that human Geminin protects CDT1 from proteasome-media...
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| Gepubliceerd in: | EMBO J |
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| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2004
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514931/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15257290/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600314 |
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