Human Geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

Geminin is an unstable inhibitor of DNA replication that negatively regulates the licensing factor CDT1 and inhibits pre-replicative complex (pre-RC) formation in Xenopus egg extracts. Here we describe a novel function of Geminin. We demonstrate that human Geminin protects CDT1 from proteasome-media...

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Pubblicato in:	EMBO J
Autori principali:	Ballabeni, Andrea, Melixetian, Marina, Zamponi, Raffaella, Masiero, Laura, Marinoni, Federica, Helin, Kristian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2004
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514931/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15257290/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600314
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