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RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies

Cajal bodies (CBs) are subnuclear organelles of animal and plant cells. A role of CBs in the assembly and maturation of small nuclear ribonucleoproteins (snRNP) has been proposed but is poorly understood. Here we have addressed the question where U4/U6.U5 tri-snRNP assembly occurs in the nucleus. Th...

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Main Authors: Schaffert, Nina, Hossbach, Markus, Heintzmann, Rainer, Achsel, Tilmann, Lührmann, Reinhard
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC514917/
https://ncbi.nlm.nih.gov/pubmed/15257298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600296
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