Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (variant...

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Bibliographic Details
Main Authors: Fairbrother, William G, Holste, Dirk, Burge, Christopher B, Sharp, Phillip A
Format: Artigo
Language:Inglês
Published: Public Library of Science 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC514884/
https://ncbi.nlm.nih.gov/pubmed/15340491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020268
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