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Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (variant...

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Détails bibliographiques
Publié dans:PLoS Biol
Auteurs principaux: Fairbrother, William G, Holste, Dirk, Burge, Christopher B, Sharp, Phillip A
Format: Artigo
Langue:Inglês
Publié: PLOS 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514884/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15340491/
https://ncbi.nlm.nih.govhttps://doi.org/10.1371/journal.pbio.0020268
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