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Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (variant...

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Detalhes bibliográficos
Main Authors: Fairbrother, William G, Holste, Dirk, Burge, Christopher B, Sharp, Phillip A
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514884/
https://ncbi.nlm.nih.gov/pubmed/15340491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020268
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