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Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (variant...

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Библиографические подробности
Опубликовано в: :PLoS Biol
Главные авторы: Fairbrother, William G, Holste, Dirk, Burge, Christopher B, Sharp, Phillip A
Формат: Artigo
Язык:Inglês
Опубликовано: PLOS 2004
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514884/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15340491/
https://ncbi.nlm.nih.govhttps://doi.org/10.1371/journal.pbio.0020268
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