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A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Innate immune signaling pathways contribute to the protection of host tissue when bacterially challenged. Colonic goblet cells are responsible for generating the two mucus layers that physically separate the luminal microbiota from the host epithelium. We report the identification of a ‘sentinel’ go...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Birchenough, George M.H., Nyström, Elisabeth E.L., Johansson, Malin E.V., Hansson, Gunnar C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148821/
https://ncbi.nlm.nih.gov/pubmed/27339979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf7419
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