Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells

BACKGROUND: Ebselen, an organoselenium compound and a clinically safe molecule has been reported to possess potent antifungal activity, but its antifungal mechanism of action and in vivo antifungal activity remains unclear. METHODS: The antifungal effect of ebselen was tested against Candida albican...

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Publicat a:Biochim Biophys Acta
Autors principals: Thangamani, Shankar, Eldesouky, Hassan E., Mohammad, Haroon, Pascuzzi, Pete E., Avramova, Larisa, Hazbun, Tony R., Seleem, Mohamed N.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148707/
https://ncbi.nlm.nih.gov/pubmed/27712973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.09.029
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