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Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-bond Donor and Lewis Base

An enantioselective, catalytic aza-Sakurai cyclization of chlorolactams has been developed as an efficient entry into indolizidine and quinolizidine frameworks. Structure-enantioselectivity relationship studies and mechanistic analysis point to a dual role of the catalyst wherein the thiourea moiety...

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Pubblicato in:J Am Chem Soc
Autori principali: Park, Yongho, Schindler, Corinna S., Jacobsen, Eric N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148636/
https://ncbi.nlm.nih.gov/pubmed/27787993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b09736
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