Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization

Most studies of the mechanisms leading to hereditary dilated cardiomyopathy (DCM) have been performed in reconstituted in vitro systems. Genetically engineered murine models offer the opportunity to dissect these mechanisms in vivo. We generated a gene-targeted knock-in murine model of the autosomal...

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Pubblicato in:PLoS One
Autori principali: Ramratnam, Mohun, Salama, Guy, Sharma, Ravi K., Wang, David Wen Rui, Smith, Stephen H., Banerjee, Sanjay K., Huang, Xueyin N., Gifford, Lindsey M., Pruce, Michele L., Gabris, Bethann E., Saba, Samir, Shroff, Sanjeev G., Ahmad, Ferhaan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147943/
https://ncbi.nlm.nih.gov/pubmed/27936050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167681
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