Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization

Most studies of the mechanisms leading to hereditary dilated cardiomyopathy (DCM) have been performed in reconstituted in vitro systems. Genetically engineered murine models offer the opportunity to dissect these mechanisms in vivo. We generated a gene-targeted knock-in murine model of the autosomal...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ramratnam, Mohun, Salama, Guy, Sharma, Ravi K., Wang, David Wen Rui, Smith, Stephen H., Banerjee, Sanjay K., Huang, Xueyin N., Gifford, Lindsey M., Pruce, Michele L., Gabris, Bethann E., Saba, Samir, Shroff, Sanjeev G., Ahmad, Ferhaan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147943/
https://ncbi.nlm.nih.gov/pubmed/27936050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167681
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