Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization

Most studies of the mechanisms leading to hereditary dilated cardiomyopathy (DCM) have been performed in reconstituted in vitro systems. Genetically engineered murine models offer the opportunity to dissect these mechanisms in vivo. We generated a gene-targeted knock-in murine model of the autosomal...

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Publicat a:PLoS One
Autors principals: Ramratnam, Mohun, Salama, Guy, Sharma, Ravi K., Wang, David Wen Rui, Smith, Stephen H., Banerjee, Sanjay K., Huang, Xueyin N., Gifford, Lindsey M., Pruce, Michele L., Gabris, Bethann E., Saba, Samir, Shroff, Sanjeev G., Ahmad, Ferhaan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147943/
https://ncbi.nlm.nih.gov/pubmed/27936050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167681
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