The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury

Macrophages have been shown to play a role in acetaminophen (APAP)-induced hepatotoxicity, contributing to both pro- and anti-inflammatory processes. In these studies, we analyzed the role of the spleen as an extramedullary source of hepatic macrophages. APAP administration (300 mg/kg, i.p.) to cont...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Mandal, Mili, Gardner, Carol R., Sun, Richard, Choi, Hyejeong, Lad, Sonali, Mishin, Vladimir, Laskin, Jeffrey D., Laskin, Debra L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147741/
https://ncbi.nlm.nih.gov/pubmed/27163765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2016.04.019
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