A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

BACKGROUND: Elevated production of reactive oxygen species (ROS) and an altered redox state have frequently been observed in hepatocellular carcinoma (HCC); therefore, selective killing of HCC cells by chemotherapeutic agents that stimulate ROS generation or impair antioxidant systems may be a feasi...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Yao, Nan, Li, Ying-jie, Lei, Yu-he, Hu, Nan, Chen, Wei-Min, Yao, Zhe, Yu, Miao, Liu, Jun-shan, Ye, Wen-cai, Zhang, Dong-mei
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146873/
https://ncbi.nlm.nih.gov/pubmed/27931237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0457-1
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