Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

BACKGROUND: Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it’s expressed by many cells but highly expressed by the choroid plexus and the predominant apolipoprotein in cerebrospinal fluid (CSF). The role of apoE in the CSF is unclear. Rece...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Neurodegener
Main Authors: Achariyar, Thiyagaragan M., Li, Baoman, Peng, Weiguo, Verghese, Philip B., Shi, Yang, McConnell, Evan, Benraiss, Abdellatif, Kasper, Tristan, Song, Wei, Takana, Takahiro, Holtzman, David M., Nedergaard, Maiken, Deane, Rashid
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146863/
https://ncbi.nlm.nih.gov/pubmed/27931262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0138-8
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