Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

BACKGROUND: Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it’s expressed by many cells but highly expressed by the choroid plexus and the predominant apolipoprotein in cerebrospinal fluid (CSF). The role of apoE in the CSF is unclear. Rece...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Achariyar, Thiyagaragan M., Li, Baoman, Peng, Weiguo, Verghese, Philip B., Shi, Yang, McConnell, Evan, Benraiss, Abdellatif, Kasper, Tristan, Song, Wei, Takana, Takahiro, Holtzman, David M., Nedergaard, Maiken, Deane, Rashid
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146863/
https://ncbi.nlm.nih.gov/pubmed/27931262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0138-8
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