MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

BACKGROUND: Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell survival and chemo-resistance in a wide range of malignancies, and thus its inhibition may prove to be therapeutically useful. M...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Young, Adelaide I. J., Law, Andrew M. K., Castillo, Lesley, Chong, Sabrina, Cullen, Hayley D., Koehler, Martin, Herzog, Sebastian, Brummer, Tilman, Lee, Erinna F., Fairlie, Walter D., Lucas, Morghan C., Herrmann, David, Allam, Amr, Timpson, Paul, Watkins, D. Neil, Millar, Ewan K. A., O’Toole, Sandra A., Gallego-Ortega, David, Ormandy, Christopher J., Oakes, Samantha R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146841/
https://ncbi.nlm.nih.gov/pubmed/27931239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0781-6
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