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L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
Mounting in vitro, in vivo and clinical evidence suggest an important role for filopodia in driving cancer cell invasion. Using a high-throughput microscopic-based drug screen, we identify FDA-approved calcium channel blockers (CCBs) as potent inhibitors of filopodia formation in cancer cells. Unexp...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5146291/ https://ncbi.nlm.nih.gov/pubmed/27910855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13297 |
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