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Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors
BACKGROUND: RNA interference (RNAi) can potently reduce target gene expression in mammalian cells and is in wide use for loss-of-function studies. Several recent reports have demonstrated that short double-stranded RNAs (dsRNAs), used to mediate RNAi, can also induce an interferon-based response res...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514603/ https://ncbi.nlm.nih.gov/pubmed/15291968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-5-9 |
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