Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways

In collapsing focal segmental glomerulosclerosis (FSGS) of HIV-associated nephropathy (HIVAN), podocytes exhibit a high proliferation rate and loss of differentiation markers. We have found previously that the nef gene of HIV-1 is responsible for these changes. Here, we investigated the signaling pa...

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Bibliographische Detailangaben
Hauptverfasser: He, John Cijiang, Husain, Mohammad, Sunamoto, Masaaki, D’Agati, Vivette D., Klotman, Mary E., Iyengar, Ravi, Klotman, Paul E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC514582/
https://ncbi.nlm.nih.gov/pubmed/15343382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421004
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