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Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends

The Ku complex binds non-specifically to DNA breaks and ensures repair via NHEJ. However, Ku is also known to bind directly to telomeric DNA ends and its presence there is associated with telomere capping, but avoiding NHEJ. How the complex discriminates between a DNA break and a telomeric extremity...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Larcher, Mélanie V., Pasquier, Emeline, MacDonald, R. Stephen, Wellinger, Raymund J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145143/
https://ncbi.nlm.nih.gov/pubmed/27930670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006479
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