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Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 is prevalently overexpressed in human cancers and implicated in oncogenesis. However, the role of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Wulf, Gerburg, Garg, Priti, Liou, Yih-Cherng, Iglehart, Dirk, Lu, Kun Ping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514501/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15257284/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600323
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