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Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis
Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 is prevalently overexpressed in human cancers and implicated in oncogenesis. However, the role of...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514501/ https://ncbi.nlm.nih.gov/pubmed/15257284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600323 |
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