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Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut

Terminating transcription is a highly intricate process for mammalian protein-coding genes. First, the chromatin template slows down transcription at the gene end. Then, the transcript is cleaved at the poly(A) signal to release the messenger RNA.The remaining transcript is selectively unraveled and...

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Bibliographic Details
Published in:Science
Main Author: Proudfoot, Nick J.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144996/
https://ncbi.nlm.nih.gov/pubmed/27284201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad9926
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