Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development

Mysm1(−/−) mice have severely decreased cellularity in hematopoietic organs. We previously revealed that Mysm1 knockout impairs self-renewal and lineage reconstitution of HSCs by abolishing the recruitment of key transcriptional factors to the Gfi-1 locus, an intrinsic regulator of HSC function. The...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Huang, X F, Nandakumar, V, Tumurkhuu, G, Wang, T, jiang, X, Hong, B, Jones, L, Won, H, Yoshii, H, Ozato, K, Masumi, A, Chen, S-Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143390/
https://ncbi.nlm.nih.gov/pubmed/27277682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.162
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