Cytomegalovirus-Specific IL-10-Producing CD4(+) T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

CD4(+) T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4(+) T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV) express the regulatory cytokine interleuki...

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Publicat a:PLoS Pathog
Autors principals: Clement, Mathew, Marsden, Morgan, Stacey, Maria A., Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana, Scurr, Martin J., Ghazal, Peter, Weaver, Casey T., Carlesso, Gianluca, Clare, Simon, Jones, Simon A., Godkin, Andrew, Jones, Gareth W., Humphreys, Ian R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142785/
https://ncbi.nlm.nih.gov/pubmed/27926930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006050
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