The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans. Here, we used the murine CMV (MCMV) model of infection to determine that IFITM3 limits h...

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Publicado en:J Clin Invest
Main Authors: Stacey, Maria A., Clare, Simon, Clement, Mathew, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A., Smith, Sarah E., Wash, Rachael S., Brias, Silvia Gimeno, Stack, Gabrielle, Notley, George, Cambridge, Emma L., Isherwood, Christopher, Speak, Anneliese O., Johnson, Zoë, Ferlin, Walter, Jones, Simon A., Kellam, Paul, Humphreys, Ian R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373880/
https://ncbi.nlm.nih.gov/pubmed/28240600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84889
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