Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

Inflammasomes are cytosolic multi-protein complexes that initiate immune responses to infection by recruiting and activating the Caspase-1 protease. Human NLRP1 was the first protein shown to form an inflammasome, but its physiological mechanism of activation remains unknown. Recently, specific vari...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Chavarría-Smith, Joseph, Mitchell, Patrick S., Ho, Alvin M., Daugherty, Matthew D., Vance, Russell E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142783/
https://ncbi.nlm.nih.gov/pubmed/27926929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006052
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