Impact of age and vector construct on striatal and nigral transgene expression

Therapeutic protein delivery using viral vectors has shown promise in preclinical models of Parkinson’s disease (PD) but clinical trial success remains elusive. This may partially be due to a failure to include advanced age as a covariate despite aging being the primary risk factor for PD. We invest...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Methods Clin Dev
Prif Awduron: Polinski, Nicole K, Manfredsson, Fredric P, Benskey, Matthew J, Fischer, D Luke, Kemp, Christopher J, Steece-Collier, Kathy, Sandoval, Ivette M, Paumier, Katrina L, Sortwell, Caryl E
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142515/
https://ncbi.nlm.nih.gov/pubmed/27933309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.82
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