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Impact of age and vector construct on striatal and nigral transgene expression
Therapeutic protein delivery using viral vectors has shown promise in preclinical models of Parkinson’s disease (PD) but clinical trial success remains elusive. This may partially be due to a failure to include advanced age as a covariate despite aging being the primary risk factor for PD. We invest...
Zapisane w:
| Wydane w: | Mol Ther Methods Clin Dev |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5142515/ https://ncbi.nlm.nih.gov/pubmed/27933309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.82 |
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