Immunogenicity of self tumor associated proteins is enhanced through protein truncation

We showed previously that therapy with Vesicular Stomatitis Virus (VSV) expressing tumor-associated proteins eradicates established tumors. We show here that when cellular cDNA were cloned into VSV which retained their own poly-A signal, viral species emerged in culture which had deleted the cellula...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Oncolytics
Auteurs principaux: Kottke, Tim, Shim, Kevin G, Alonso-Camino, Vanesa, Zaidi, Shane, Maria Diaz, Rosa, Pulido, Jose, Thompson, Jill, Rajani, Karishma R, Evgin, Laura, Ilett, Elizabeth, Pandha, Hardev, Harrington, Kevin, Selby, Peter, Melcher, Alan, Vile, Richard
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142466/
https://ncbi.nlm.nih.gov/pubmed/27933315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.30
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