Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat

We showed previously that Bacillus anthracis edema toxin (ET), comprised of protective antigen (PA) and edema factor (EF), inhibits phenylephrine (PE)-induced contraction in rat aortic rings and these effects are diminished in endothelial-denuded rings. Therefore, employing rat aortic ring and in vi...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Li, Yan, Cui, Xizhong, Xu, Wanying, Ohanjanian, Lernik, Sampath-Kumar, Hanish, Suffredini, Dante, Moayeri, Mahtab, Leppla, Stephen, Fitz, Yvonne, Eichacker, Peter Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142181/
https://ncbi.nlm.nih.gov/pubmed/27448553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00163.2016
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