Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise, and Metabolic and Excitatory Challenges

The impact of mitochondrial protein acetylation status on neuronal function and vulnerability to neurological disorders is unknown. Here we show that the mitochondrial protein deacetylase SIRT3 mediates adaptive responses of neurons to bioenergetic, oxidative and excitatory stress. Cortical neurons...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Cheng, Aiwu, Yang, Ying, Zhou, Ye, Maharana, Chinmoyee, Lu, Daoyuan, Peng, Wei, Liu, Yong, Wan, Ruiqian, Marosi, Krisztina, Misiak, Magdalena, Bohr, Vilhelm A., Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141613/
https://ncbi.nlm.nih.gov/pubmed/26698917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.10.013
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