NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury

NADPH oxidase 4 (NOX4) is highly expressed in kidney proximal tubular cells. NOX4 constitutively produces hydrogen peroxide, which may regulate important pro-survival pathways. Renal ischemia reperfusion injury (IRI) is a classical model mimicking human ischemic acute tubular necrosis. We hypothesiz...

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Опубликовано в: :Sci Rep
Главные авторы: Nlandu-Khodo, Stellor, Dissard, Romain, Hasler, Udo, Schäfer, Matthias, Pircher, Haymo, Jansen-Durr, Pidder, Krause, Karl Heinz, Martin, Pierre-Yves, de Seigneux, Sophie
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141508/
https://ncbi.nlm.nih.gov/pubmed/27924932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38598
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