Time-resolved Analysis of Proteome Dynamics by Tandem Mass Tags and Stable Isotope Labeling in Cell Culture (TMT-SILAC) Hyperplexing

Recent advances in mass spectrometry have enabled system-wide analyses of protein turnover. By globally quantifying the kinetics of protein clearance and synthesis, these methodologies can provide important insights into the regulation of the proteome under varying cellular and environmental conditi...

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Publicat a:Mol Cell Proteomics
Autors principals: Welle, Kevin A., Zhang, Tian, Hryhorenko, Jennifer R., Shen, Shichen, Qu, Jun, Ghaemmaghami, Sina
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141271/
https://ncbi.nlm.nih.gov/pubmed/27765818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.063230
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