Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

HLA-DR molecules are heterodimeric transmembrane glycoproteins that associate intracellularly with a polypeptide known as the invariant (I) chain. Shortly before expression of the HLA-DR alpha beta dimer on the cell surface, however, the I chain is removed from the intracellular alpha beta I complex...

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Detalles Bibliográficos
Autores principales: Roche, P A, Cresswell, P
Formato: Artigo
Lenguaje:Inglês
Publicado: 1991
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC51403/
https://ncbi.nlm.nih.gov/pubmed/2014234
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