Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.
HLA-DR molecules are heterodimeric transmembrane glycoproteins that associate intracellularly with a polypeptide known as the invariant (I) chain. Shortly before expression of the HLA-DR alpha beta dimer on the cell surface, however, the I chain is removed from the intracellular alpha beta I complex...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51403/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2014234/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.8.3150 |
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