Neuroblastoma patients with high-affinity FCGR2A, -3A and stimulatory KIR 2DS2 treated by long-term infusion of anti-GD(2) antibody ch14.18/CHO show higher ADCC levels and improved event-free survival

Polymorphisms in Fc-gamma-receptor (FCGR) genes as well as killer cell immunoglobulin-like receptor (KIR) and KIR ligand (KIRL) repertoires may influence antitumor effects of monoclonal antibodies (mAb). Here, we systematically analyzed high- and low-affinity FCGR2A and -3A genotypes as well as stim...

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Vydáno v:Oncoimmunology
Hlavní autoři: Siebert, Nikolai, Jensen, Christian, Troschke-Meurer, Sascha, Zumpe, Maxi, Jüttner, Madlen, Ehlert, Karoline, Kietz, Silke, Müller, Ina, Lode, Holger N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139629/
https://ncbi.nlm.nih.gov/pubmed/27999754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1235108
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