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Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve

Cisplatin is an effective chemotherapy drug that induces peripheral neuropathy in cancer patients. In rodent dorsal root ganglion neurons, cisplatin binds nuclear and mitochondrial DNA (mtDNA) inducing DNA damage and apoptosis. Platinum-mtDNA adducts inhibit mtDNA replication and transcription leadi...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Podratz, Jewel L., Lee, Han, Knorr, Patrizia, Koehler, Stephanie, Forsythe, Steven, Lambrecht, Kelsey, Arias, Suzette, Schmidt, Kiley, Steinhoff, Gabrielle, Yudintsev, Georgiy, Yang, Amy, Trushina, Eugenia, Windebank, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138083/
https://ncbi.nlm.nih.gov/pubmed/27765583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.10.003
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