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Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve
Cisplatin is an effective chemotherapy drug that induces peripheral neuropathy in cancer patients. In rodent dorsal root ganglion neurons, cisplatin binds nuclear and mitochondrial DNA (mtDNA) inducing DNA damage and apoptosis. Platinum-mtDNA adducts inhibit mtDNA replication and transcription leadi...
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| Publicado no: | Neurobiol Dis |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5138083/ https://ncbi.nlm.nih.gov/pubmed/27765583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.10.003 |
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