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Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons

Bortezomib is part of a newer class of chemotherapeutic agents whose mechanism of action is inhibition of the proteasome-ubiquitination system. Primarily used in multiple myeloma, bortezomib causes a sensory-predominant axonal peripheral neuropathy in approximately 30% of patients. There are no esta...

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Main Authors: Staff, Nathan P., Podratz, Jewel L., Grassner, Lukas, Bader, Miranda, Paz, Justin, Knight, Andrew M., Loprinzi, Charles L., Trushina, Eugenia, Windebank, Anthony J.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844018/
https://ncbi.nlm.nih.gov/pubmed/24035926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.09.001
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