Development and validation of a clinical HPLC method for the quantification of hydroxychloroquine and its metabolites in whole blood

BACKGROUND: Therapeutic drug monitoring for hydroxychloroquine (HCQ) has been suggested to assess nonadherence and optimize treatment efficacy in systemic lupus erythematosus patients. MATERIALS & METHODS: After protein precipitation, HCQ and its metabolites, desethylhydroxychloroquine and deset...

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Bibliographic Details
Published in:Future Sci OA
Main Authors: Qu, Ying, Noe, Gaelle, Breaud, Autumn R, Vidal, Michel, Clarke, William A, Zahr, Noel, Dervieux, Thierry, Costedoat-Chalumeau, Nathalie, Blanchet, Benoit
Format: Artigo
Language:Inglês
Published: Future Science Ltd 2015
Subjects:
Methodology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137978/
https://ncbi.nlm.nih.gov/pubmed/28031899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fso.15.24
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