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Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer
Endonuclease G (EndoG) is an evolutionarily conserved mitochondrial protein in eukaryotes that digests nucleus chromosomal DNA during apoptosis and paternal mitochondrial DNA during embryogenesis. Under oxidative stress, homodimeric EndoG becomes oxidized and converts to monomers with diminished nuc...
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| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137453/ https://ncbi.nlm.nih.gov/pubmed/27738134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw931 |
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