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Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation
Human polynucleotide phosphorylase (hPNPase) is a 3′-to-5′ exoribonuclease that degrades specific mRNA and miRNA, and imports RNA into mitochondria, and thus regulates diverse physiological processes, including cellular senescence and homeostasis. However, the RNA-processing mechanism by hPNPase, pa...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351181/ https://ncbi.nlm.nih.gov/pubmed/22210891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1281 |
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