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Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities
Human polynucleotide phosphorylase (PNPase) is an evolutionarily conserved 3′-to-5′ exoribonuclease principally located in mitochondria where it is responsible for RNA turnover and import. Mutations in PNPase impair structured RNA transport into mitochondria, resulting in mitochondrial dysfunction a...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6144817/ https://ncbi.nlm.nih.gov/pubmed/30020492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky642 |
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