Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities

Human polynucleotide phosphorylase (PNPase) is an evolutionarily conserved 3′-to-5′ exoribonuclease principally located in mitochondria where it is responsible for RNA turnover and import. Mutations in PNPase impair structured RNA transport into mitochondria, resulting in mitochondrial dysfunction a...

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Publicat a:Nucleic Acids Res
Autors principals: Golzarroshan, Bagher, Lin, Chia-Liang, Li, Chia-Lung, Yang, Wei-Zen, Chu, Lee-Ya, Agrawal, Sashank, Yuan, Hanna S
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144817/
https://ncbi.nlm.nih.gov/pubmed/30020492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky642
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