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Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions

The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents. These transporters reduce intracellular drug concentrations to subtoxic levels by mediating drug efflux across the cell env...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Nair, Asha V., Singh, Himansha, Raturi, Sagar, Neuberger, Arthur, Tong, Zhen, Ding, Ning, Agboh, Kelvin, van Veen, Hendrik W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137110/
https://ncbi.nlm.nih.gov/pubmed/27917857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38052
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