Host cell mTORC1 is required for HCV RNA replication

OBJECTIVE: Chronically HCV-infected orthotopic liver transplantation (OLT) recipients appear to have improved outcomes when their immunosuppressive regimen includes a mammalian target of rapamycin (mTOR) inhibitor. The mechanism underlying this observation is unknown. DESIGN: We used virological ass...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Stöhr, Stefanie, Costa, Rui, Sandmann, Lisa, Westhaus, Sandra, Pfaender, Stephanie, Anggakusuma, Dazert, Eva, Meuleman, Philip, Vondran, Florian W R, Manns, Michael P, Steinmann, Eike, von Hahn, Thomas, Ciesek, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Hepatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136730/
https://ncbi.nlm.nih.gov/pubmed/26276683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-308971
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