HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

OBJECTIVE: HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We analysed the in vivo role of hypervariable region 1 (HVR1) for HCV virion properties, including nAb susceptibility. DESIGN: Analysis of...

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Publicado en:Gut
Autores principales: Prentoe, Jannick, Verhoye, Lieven, Velázquez Moctezuma, Rodrigo, Buysschaert, Caroline, Farhoudi, Ali, Wang, Richard, Alter, Harvey, Meuleman, Philip, Bukh, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2016
Materias:
Hepatology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136728/
https://ncbi.nlm.nih.gov/pubmed/26589670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310300
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