Alkylating agent induced NRF2 blocks endoplasmic reticulum stress-mediated apoptosis via control of glutathione pools and protein thiol homeostasis

Alkylating agents are a commonly used cytotoxic class of anticancer drugs. Understanding the mechanisms whereby cells respond to these drugs is key to identify means to improve therapy while reducing toxicity. By integrating genome-wide gene expression profiling, protein analysis and functional cell...

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Pubblicato in:Mol Cancer Ther
Autori principali: Zanotto-Filho, Alfeu, Masamsetti, V. Pragathi, Loranc, Eva, Tonapi, Sonal S., Gorthi, Aparna, Bernard, Xavier, Gonçalves, Rosângela Mayer, Moreira, José C. F., Chen, Yidong, Bishop, Alexander J. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136348/
https://ncbi.nlm.nih.gov/pubmed/27638861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0271
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